› › Function and Biology

Novel 5-Azaindole Factor VIIa Inhibitors

Source organism: Homo sapiens
Biochemical function: calcium ion binding
Biological process: blood coagulation
Cellular component: membrane

Quick links

EC 3.4.21.21: Coagulation factor VIIa

Reaction catalysed:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
Alternative Name(s):
  • Activated blood coagulation factor VII
  • Blood-coagulation factor VIIa

GO terms

Sequence families

Pfam Protein families (Pfam)
PF09294
Domain description: Interferon-alpha/beta receptor, fibronectin type III
Occurring in:
  1. Tissue factor

PF01108
Domain description: Tissue factor
Occurring in:
  1. Tissue factor

PF14670
Domain description: Coagulation Factor Xa inhibitory site
Occurring in:
  1. Factor VII light chain

PF00008
Domain description: EGF-like domain
Occurring in:
  1. Factor VII light chain

PF00594
Domain description: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
Occurring in:
  1. Factor VII light chain

PF00089
Domain description: Trypsin
Occurring in:
  1. Factor VII heavy chain

InterPro InterPro annotations
IPR001187
Domain description: Tissue factor
Occurring in:
  1. Tissue factor
IPR000294
Domain description: Gamma-carboxyglutamic acid-rich (GLA) domain
Occurring in:
  1. Factor VII light chain
IPR000742
Domain description: EGF-like domain
Occurring in:
  1. Factor VII light chain
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Factor VII heavy chain
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Factor VII heavy chain
IPR036116
Domain description: Fibronectin type III superfamily
Occurring in:
  1. Tissue factor
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Tissue factor
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Factor VII heavy chain
IPR015373
Domain description: Interferon/interleukin receptor domain
Occurring in:
  1. Tissue factor
IPR030472
Domain description: Tissue factor, conserved site
Occurring in:
  1. Tissue factor
IPR003961
Domain description: Fibronectin type III
Occurring in:
  1. Tissue factor
IPR000152
Domain description: EGF-type aspartate/asparagine hydroxylation site
Occurring in:
  1. Factor VII light chain
IPR018097
Domain description: EGF-like calcium-binding, conserved site
Occurring in:
  1. Factor VII light chain
IPR001881
Domain description: EGF-like calcium-binding domain
Occurring in:
  1. Factor VII light chain
IPR035972
Domain description: Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Occurring in:
  1. Factor VII light chain
IPR017857
Domain description: Coagulation factor-like, Gla domain superfamily
Occurring in:
  1. Factor VII light chain
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Factor VII heavy chain
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Factor VII heavy chain
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Factor VII heavy chain

Structure domains

CATH CATH domains
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Factor VII heavy chain
2.10.25.10
Class: Mainly Beta
Architecture: Ribbon
Topology: Laminin
Homology: Laminin
Occurring in:
  1. Factor VII light chain
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Tissue factor
SCOP SCOP annotations
49266
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Fibronectin type III
Occurring in:
  1. Tissue factor
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Factor VII heavy chain

Quick links