› 2fp2

X-ray diffraction
1.64Å resolution

Secreted Chorismate Mutase from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb2fp2/pdb
PDB entry 2fp2 coloured by chain, front view.
PDB entry 2fp2 coloured by chain, side view.
PDB entry 2fp2 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
1.6 A crystal structure of the secreted chorismate mutase from Mycobacterium tuberculosis: novel fold topology revealed.
Okvist M, Dey R, Sasso S, Grahn E, Kast P, Krengel U
J Mol Biol 357 1483-99 (2006)
PMID: 16499927

Function and Biology Details

Reaction catalysed: 
Chorismate = prephenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Secreted chorismate mutase Chains: A, B
Molecule details ›
Chains: A, B
Length: 166 amino acids
Theoretical weight: 18.5 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WIB9 (Residues: 34-199; Coverage: 100%)
Gene name: Rv1885c
Sequence domains: Chorismate mutase type II
Structure domains: Chorismate mutase

Ligands and Environments

1 bound ligand:
Ligand TSA 1 x TSA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21
Unit cell:
a: 42.906Å b: 72.8Å c: 61.716Å
α: 90° β: 103.99° γ: 90°
R-values:
R R work R free
0.172 0.17 0.203
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Protein design by directed evolution.
Jäckel et al. (2008)
5 more

14 mentions without citation

Testing of the GROMOS Force-Field Parameter Set 54A8: Structural Properties of Electrolyte Solutions, Lipid Bilayers, and Proteins.
Reif et al. (2013)
13 more