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Crystal structure of Geranyltranstransferase (EC 2.5.1.10) (tm0161) from THERMOTOGA MARITIMA at 1.90 A resolution

Source organism: Thermotoga maritima MSB8
Biochemical function: transferase activity
Biological process: geranylgeranyl diphosphate biosynthetic process
Cellular component: not assigned

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EC 2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

Reaction catalysed:
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Systematic name:
Geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase
Alternative Name(s):
  • FPP synthetase
  • Farnesyl pyrophosphate synthetase
  • Farnesyl-diphosphate synthase
  • Farnesylpyrophosphate synthetase
  • Geranyl transferase I
  • Geranyltranstransferase
  • Prenyltransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00348
Domain description: Polyprenyl synthetase
Occurring in:
  1. Geranyltranstransferase
The deposited structure of PDB entry 2ftz contains 1 copy of Pfam domain PF00348 (Polyprenyl synthetase) in Geranyltranstransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR033749
Domain description: Polyprenyl synthetase, conserved site
Occurring in:
  1. Geranyltranstransferase
IPR000092
Domain description: Polyprenyl synthetase
Occurring in:
  1. Geranyltranstransferase
IPR008949
Domain description: Isoprenoid synthase domain superfamily
Occurring in:
  1. Geranyltranstransferase

Structure domain

CATH CATH domain
1.10.600.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Farnesyl Diphosphate Synthase
Homology: Farnesyl Diphosphate Synthase
Occurring in:
  1. Geranyltranstransferase
The deposited structure of PDB entry 2ftz contains 1 copy of CATH domain 1.10.600.10 (Farnesyl Diphosphate Synthase) in Geranyltranstransferase. Showing 1 copy in chain A.

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