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Crystal structure of MthK rck domain in its ligand-free gating-ring form

Source organism: Methanothermobacter thermautotrophicus
Biochemical function: monoatomic cation transmembrane transporter activity
Biological process: potassium ion transport
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02080
Domain description: TrkA-C domain
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of Pfam domain PF02080 (TrkA-C domain) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.

PF02254
Domain description: TrkA-N domain
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of Pfam domain PF02254 (TrkA-N domain) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036721
Domain description: Regulator of K+ conductance, C-terminal domain superfamily
Occurring in:
  1. Calcium-gated potassium channel MthK
IPR006037
Domain description: Regulator of K+ conductance, C-terminal
Occurring in:
  1. Calcium-gated potassium channel MthK
IPR003148
Domain description: Regulator of K+ conductance, N-terminal
Occurring in:
  1. Calcium-gated potassium channel MthK
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. Calcium-gated potassium channel MthK

Structure domains

CATH CATH domains
3.30.70.1450
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Regulator of K+ conductance, C-terminal domain
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of CATH domain 3.30.70.1450 (Alpha-Beta Plaits) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.
1.20.5.870
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Voltage-gated potassium channel
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of CATH domain 1.20.5.870 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of CATH domain 3.40.50.720 (Rossmann fold) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.
SCOP SCOP annotations
116727
Class: Alpha and beta proteins (a+b)
Fold: TrkA C-terminal domain-like
Superfamily: TrkA C-terminal domain-like
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of SCOP domain 116727 (TrkA C-terminal domain-like) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.
63944
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. Calcium-gated potassium channel MthK
The deposited structure of PDB entry 2fy8 contains 8 copies of SCOP domain 63944 (Potassium channel NAD-binding domain) in Calcium-gated potassium channel MthK. Showing 1 copy in chain A.

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