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Structure of QacR Multidrug Transcriptional Regulator Bound to Trivalent and Bivalent Diamidine Drugs

Source organism: Staphylococcus haemolyticus
Biochemical function: DNA-binding transcription factor activity
Biological process: negative regulation of DNA-templated transcription
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF08360
Domain description: QacR-like protein, C-terminal region
Occurring in:
  1. HTH-type transcriptional regulator QacR
The deposited structure of PDB entry 2g0e contains 4 copies of Pfam domain PF08360 (QacR-like protein, C-terminal region) in HTH-type transcriptional regulator QacR. Showing 1 copy in chain A.

PF00440
Domain description: Bacterial regulatory proteins, tetR family
Occurring in:
  1. HTH-type transcriptional regulator QacR
The deposited structure of PDB entry 2g0e contains 4 copies of Pfam domain PF00440 (Bacterial regulatory proteins, tetR family) in HTH-type transcriptional regulator QacR. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001647
Domain description: DNA-binding HTH domain, TetR-type
Occurring in:
  1. HTH-type transcriptional regulator QacR
IPR036271
Domain description: Tetracyclin repressor-like, C-terminal domain superfamily
Occurring in:
  1. HTH-type transcriptional regulator QacR
IPR013571
Domain description: Transcription regulator QacR, C-terminal
Occurring in:
  1. HTH-type transcriptional regulator QacR
IPR023772
Domain description: DNA-binding HTH domain, TetR-type, conserved site
Occurring in:
  1. HTH-type transcriptional regulator QacR
IPR009057
Domain description: Homedomain-like superfamily
Occurring in:
  1. HTH-type transcriptional regulator QacR

Structure domains

CATH CATH domains
1.10.357.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Tetracycline Repressor; domain 2
Homology: Tetracycline Repressor, domain 2
Occurring in:
  1. HTH-type transcriptional regulator QacR
The deposited structure of PDB entry 2g0e contains 4 copies of CATH domain 1.10.357.10 (Tetracycline Repressor; domain 2) in HTH-type transcriptional regulator QacR. Showing 1 copy in chain A.
1.10.10.60
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Homeodomain-like
Occurring in:
  1. HTH-type transcriptional regulator QacR
The deposited structure of PDB entry 2g0e contains 4 copies of CATH domain 1.10.10.60 (Arc Repressor Mutant, subunit A) in HTH-type transcriptional regulator QacR. Showing 1 copy in chain A.
SCOP SCOP annotations
48499
Class: All alpha proteins
Fold: Tetracyclin repressor-like, C-terminal domain
Superfamily: Tetracyclin repressor-like, C-terminal domain
Occurring in:
  1. HTH-type transcriptional regulator QacR
The deposited structure of PDB entry 2g0e contains 4 copies of SCOP domain 48499 (Tetracyclin repressor-like, C-terminal domain) in HTH-type transcriptional regulator QacR. Showing 1 copy in chain A.
46764
Class: All alpha proteins
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: Homeodomain-like
Occurring in:
  1. HTH-type transcriptional regulator QacR
The deposited structure of PDB entry 2g0e contains 4 copies of SCOP domain 46764 (Tetracyclin repressor-like, N-terminal domain) in HTH-type transcriptional regulator QacR. Showing 1 copy in chain A.

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