Function and Biology

The structure of N-acetyl-gamma-glutamyl-phosphate reductase from Salmonella typhimurium.

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Biochemical function: NADP+ binding
Biological process: L-arginine biosynthetic process
Cellular component: cytoplasm

EC 1.2.1.38: N-acetyl-gamma-glutamyl-phosphate reductase

Reaction catalysed:
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-L-glutamyl 5-phosphate + NADPH
Systematic name:
N-acetyl-L-glutamate-5-semialdehyde:NADP(+) 5-oxidoreductase (phosphorylating)
Alternative Name(s):
  • N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
  • N-acetyl-glutamate semialdehyde dehydrogenase
  • N-acetylglutamate 5-semialdehyde dehydrogenase
  • N-acetylglutamic gamma-semialdehyde dehydrogenase
  • NAGSA dehydrogenase
  • Reductase, acetyl-gamma-glutamyl phosphate

Sequence families

Pfam Protein families (Pfam)
PF22698
Domain description: Semialdehyde dehydrogenase, dimerisation domain
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
The deposited structure of PDB entry 2g17 contains 1 copy of Pfam domain PF22698 (Semialdehyde dehydrogenase, dimerisation domain) in N-acetyl-gamma-glutamyl-phosphate reductase. Showing 1 copy in chain A.

PF01118
Domain description: Semialdehyde dehydrogenase, NAD binding domain
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
The deposited structure of PDB entry 2g17 contains 1 copy of Pfam domain PF01118 (Semialdehyde dehydrogenase, NAD binding domain) in N-acetyl-gamma-glutamyl-phosphate reductase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000534
Domain description: Semialdehyde dehydrogenase, NAD-binding
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
IPR000706
Domain description: N-acetyl-gamma-glutamyl-phosphate reductase, type 1
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
IPR012280
Domain description: Semialdehyde dehydrogenase, dimerisation domain
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
IPR023013
Domain description: N-acetyl-gamma-glutamyl-phosphate reductase, active site
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
The deposited structure of PDB entry 2g17 contains 1 copy of CATH domain 3.40.50.720 (Rossmann fold) in N-acetyl-gamma-glutamyl-phosphate reductase. Showing 1 copy in chain A.
3.30.360.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dihydrodipicolinate Reductase; domain 2
Homology: Dihydrodipicolinate Reductase; domain 2
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
The deposited structure of PDB entry 2g17 contains 1 copy of CATH domain 3.30.360.10 (Dihydrodipicolinate Reductase; domain 2) in N-acetyl-gamma-glutamyl-phosphate reductase. Showing 1 copy in chain A.
SCOP SCOP annotations
51800
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
The deposited structure of PDB entry 2g17 contains 1 copy of SCOP domain 51800 (Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain) in N-acetyl-gamma-glutamyl-phosphate reductase. Showing 1 copy in chain A.
55348
Class: Alpha and beta proteins (a+b)
Fold: FwdE/GAPDH domain-like
Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain
Occurring in:
  1. N-acetyl-gamma-glutamyl-phosphate reductase
The deposited structure of PDB entry 2g17 contains 1 copy of SCOP domain 55348 (GAPDH-like) in N-acetyl-gamma-glutamyl-phosphate reductase. Showing 1 copy in chain A.