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Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A derivative, Form-I (RT)

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: kinase activity
Biological process: phosphorylation
Cellular component: plasma membrane

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EC 2.7.1.33: Pantothenate kinase

Reaction catalysed:
ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate
Systematic name:
ATP:(R)-pantothenate 4'-phosphotransferase
Alternative Name(s):
  • ATP:pantothenate 4'-phosphotransferase
  • D-pantothenate kinase
  • Pantothenate kinase (phosphorylating)
  • Pantothenic acid kinase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00485
Domain description: Phosphoribulokinase / Uridine kinase family
Occurring in:
  1. Pantothenate kinase
The deposited structure of PDB entry 2ges contains 1 copy of Pfam domain PF00485 (Phosphoribulokinase / Uridine kinase family) in Pantothenate kinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004566
Domain description: Pantothenate kinase
Occurring in:
  1. Pantothenate kinase
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Pantothenate kinase
IPR006083
Domain description: Phosphoribulokinase/uridine kinase
Occurring in:
  1. Pantothenate kinase

Structure domain

CATH CATH domain
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Pantothenate kinase
The deposited structure of PDB entry 2ges contains 1 copy of CATH domain 3.40.50.300 (Rossmann fold) in Pantothenate kinase. Showing 1 copy in chain A.

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