› 2gfy

X-ray diffraction
2.85Å resolution

Function and Biology Details

Reaction catalysed: 
A (Z)-hexadec-9-enoyl-[acyl-carrier protein] + a malonyl-[acyl-carrier protein] = a (Z)-3-oxooctadec-11-enoyl-[acyl-carrier protein] + CO(2) + an [acyl-carrier protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-141989 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-oxoacyl-[acyl-carrier-protein] synthase 2 Chain: A
Molecule details ›
Chain: A
Length: 427 amino acids
Theoretical weight: 44.58 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0AAI5 (Residues: 2-413; Coverage: 100%)
Gene names: JW1081, b1095, fabF, fabJ
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand DAO 1 x DAO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3121
Unit cell:
a: 74.73Å b: 74.73Å c: 148.072Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.169 0.166 0.243
Expression system: Escherichia coli

Quick links

Citations

140 review citations

Antibiotics for emerging pathogens.
Fischbach et al. (2009)
139 more

15 mentions without citation

Using modern tools to probe the structure-function relationship of fatty acid synthases.
Finzel et al. (2015)
14 more