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THREE-DIMENSIONAL STRUCTURE OF CHYMOTRYPSIN INACTIVATED WITH (2S) N-ACETYL-L-ALANYL-L-PHENYLALANYL-CHLOROETHYL KETONE: IMPLICATIONS FOR THE MECHANISM OF INACTIVATION OF SERINE PROTEASES BY CHLOROKETONES

Source organism: Bos taurus
Biochemical function: serine-type endopeptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.21.1: Chymotrypsin

Reaction catalysed:
Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.
Systematic name:
-
Alternative Name(s):
  • Alpha-chymar
  • Alpha-chymar ophth
  • Alpha-chymotrypsin
  • Alpha-chymotrypsin A
  • Avazyme
  • Chymar
  • Chymotest
  • Chymotrypsin A
  • Chymotrypsin B
  • Chymotrypsins A and B
  • Enzeon
  • Quimar
  • Quimotrase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00089
Domain description: Trypsin
Occurring in:
  1. Chymotrypsin A chain B
  2. Chymotrypsin A chain C
The deposited structure of PDB entry 2gmt contains 1 copy of Pfam domain PF00089 (Trypsin) in Chymotrypsin A chain B. Showing 1 copy in chain B.
The deposited structure of PDB entry 2gmt contains 1 copy of Pfam domain PF00089 (Trypsin) in Chymotrypsin A chain C. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR001254
Domain description: Serine proteases, trypsin domain
Occurring in:
  1. Chymotrypsin A chain B
  2. Chymotrypsin A chain C
IPR001314
Domain description: Peptidase S1A, chymotrypsin family
Occurring in:
  1. Chymotrypsin A chain B
IPR043504
Domain description: Peptidase S1, PA clan, chymotrypsin-like fold
Occurring in:
  1. Chymotrypsin A chain B
  2. Chymotrypsin A chain C
IPR009003
Domain description: Peptidase S1, PA clan
Occurring in:
  1. Chymotrypsin A chain B
  2. Chymotrypsin A chain C
IPR033116
Domain description: Serine proteases, trypsin family, serine active site
Occurring in:
  1. Chymotrypsin A chain C
IPR018114
Domain description: Serine proteases, trypsin family, histidine active site
Occurring in:
  1. Chymotrypsin A chain B

Structure domain

CATH CATH domain
2.40.10.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Thrombin, subunit H
Homology: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsin A chain B
  2. Chymotrypsin A chain C
The deposited structure of PDB entry 2gmt contains 1 copy of CATH domain 2.40.10.10 (Thrombin, subunit H) in Chymotrypsin A chain B. Showing 1 copy in chain B.
The deposited structure of PDB entry 2gmt contains 1 copy of CATH domain 2.40.10.10 (Thrombin, subunit H) in Chymotrypsin A chain C. Showing 1 copy in chain C.
SCOP SCOP annotation
50514
Class: All beta proteins
Fold: Trypsin-like serine proteases
Superfamily: Trypsin-like serine proteases
Occurring in:
  1. Chymotrypsin A chain A
The deposited structure of PDB entry 2gmt contains 1 copy of SCOP domain 50514 (Eukaryotic proteases) in Chymotrypsin A chain A. Showing 1 copy in chain A.

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