› 2gnc

X-ray diffraction
1.8Å resolution

Crystal structure of srGAP1 SH3 domain in the slit-robo signaling pathway

Released:
DOI: 10.2210/pdb2gnc/pdb
PDB entry 2gnc coloured by chain, front view.
PDB entry 2gnc coloured by chain, side view.
PDB entry 2gnc coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway.
Li X, Chen Y, Liu Y, Gao J, Gao F, Bartlam M, Wu JY, Rao Z
J Biol Chem 281 28430-7 (2006)
PMID: 16857672

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SLIT-ROBO Rho GTPase-activating protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 60 amino acids
Theoretical weight: 6.75 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q91Z69 (Residues: 725-776; Coverage: 5%)
Gene names: Arhgap13, Srgap1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P23
Unit cell:
a: 70.321Å b: 70.321Å c: 70.321Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.208 0.257
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Dynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins.
Suetsugu et al. (2014)
4 more

2 mentions without citation

Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway.
Li et al. (2006)
1 more