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Crystal Structure of Human Dihydropyrimidinease-like 2

Source organism: Homo sapiens
Biochemical function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological process: not assigned
Cellular component: cytoplasm

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EC 3.5.2.2: Dihydropyrimidinase

Reaction catalysed:
5,6-dihydrouracil + H(2)O = 3-ureidopropanoate
Systematic name:
5,6-dihydropyrimidine amidohydrolase
Alternative Name(s):
  • D-hydantoinase
  • Hydantoin peptidase
  • Hydantoinase
  • Hydropyrimidine hydrase
  • Pyrimidine hydrase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF01979
Domain description: Amidohydrolase family
Occurring in:
  1. Dihydropyrimidinase-related protein 2
The deposited structure of PDB entry 2gse contains 4 copies of Pfam domain PF01979 (Amidohydrolase family) in Dihydropyrimidinase-related protein 2. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR011059
Domain description: Metal-dependent hydrolase, composite domain superfamily
Occurring in:
  1. Dihydropyrimidinase-related protein 2
IPR011778
Domain description: Hydantoinase/dihydropyrimidinase
Occurring in:
  1. Dihydropyrimidinase-related protein 2
IPR032466
Domain description: Metal-dependent hydrolase
Occurring in:
  1. Dihydropyrimidinase-related protein 2
IPR006680
Domain description: Amidohydrolase-related
Occurring in:
  1. Dihydropyrimidinase-related protein 2

Structure domains

CATH CATH domains
2.30.40.10
Class: Mainly Beta
Architecture: Roll
Topology: Urease, subunit C; domain 1
Homology: Urease, subunit C, domain 1
Occurring in:
  1. Dihydropyrimidinase-related protein 2
The deposited structure of PDB entry 2gse contains 4 copies of CATH domain 2.30.40.10 (Urease, subunit C; domain 1) in Dihydropyrimidinase-related protein 2. Showing 1 copy in chain D.
3.20.20.140
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Metal-dependent hydrolases
Occurring in:
  1. Dihydropyrimidinase-related protein 2
The deposited structure of PDB entry 2gse contains 4 copies of CATH domain 3.20.20.140 (TIM Barrel) in Dihydropyrimidinase-related protein 2. Showing 1 copy in chain D.

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