EC 2.5.1.18: Glutathione transferase
Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
- Glutathione S-alkyl transferase
- Glutathione S-alkyltransferase
- Glutathione S-aralkyltransferase
- Glutathione S-aryltransferase
- Glutathione S-transferase
- S-(hydroxyalkyl)glutathione lyase
GO terms
Biochemical function:
- nitric oxide binding
- dinitrosyl-iron complex binding
- S-nitrosoglutathione binding
- protein serine/threonine kinase inhibitor activity
- protein kinase binding
- transferase activity
- toxic substance binding
- JUN kinase binding
- protein binding
- fatty acid binding
- glutathione peroxidase activity
- glutathione transferase activity
Biological process:
- negative regulation of extrinsic apoptotic signaling pathway
- negative regulation of vascular associated smooth muscle cell proliferation
- glutathione derivative biosynthetic process
- cellular oxidant detoxification
- negative regulation of smooth muscle cell chemotaxis
- negative regulation of monocyte chemotactic protein-1 production
- cellular response to cell-matrix adhesion
- cellular response to glucocorticoid stimulus
- cellular response to epidermal growth factor stimulus
- cellular response to lipopolysaccharide
- negative regulation of leukocyte proliferation
- negative regulation of ERK1 and ERK2 cascade
- regulation of ERK1 and ERK2 cascade
- hepoxilin biosynthetic process
- negative regulation of fibroblast proliferation
- negative regulation of JNK cascade
- response to ethanol
- linoleic acid metabolic process
- negative regulation of MAPK cascade
- response to amino acid
- negative regulation of canonical NF-kappaB signal transduction
- negative regulation of apoptotic process
- nitric oxide storage
- common myeloid progenitor cell proliferation
- response to L-ascorbic acid
- positive regulation of superoxide anion generation
- negative regulation of stress-activated MAPK cascade
- regulation of stress-activated MAPK cascade
- cellular response to insulin stimulus
- negative regulation of tumor necrosis factor production
- negative regulation of interleukin-1 beta production
- response to estradiol
- response to nutrient levels
- animal organ regeneration
- oligodendrocyte development
- negative regulation of tumor necrosis factor-mediated signaling pathway
- response to toxic substance
- central nervous system development
- xenobiotic metabolic process
- glutathione metabolic process
- prostaglandin metabolic process
- lipid metabolic process
- negative regulation of acute inflammatory response
- response to reactive oxygen species
- negative regulation of transcription by RNA polymerase II
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.40.30.10
Class:
Alpha Beta
Architecture:
3-Layer(aba) Sandwich
Topology:
Glutaredoxin
Homology:
Glutaredoxin
Occurring in:
SCOP annotations
