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Crystal Structure of an Aspartoacylase from Rattus norvegicus

Source organism: Rattus norvegicus
Biochemical function: metal ion binding
Biological process: positive regulation of oligodendrocyte differentiation
Cellular component: cytosol

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EC 3.5.1.15: Aspartoacylase

Reaction catalysed:
N-acyl-L-aspartate + H(2)O = a carboxylate + L-aspartate
Systematic name:
N-acyl-L-aspartate amidohydrolase
Alternative Name(s):
  • Acetyl-aspartic deaminase
  • Acylase II
  • Aminoacylase II
  • N-acetylaspartate amidohydrolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF04952
Domain description: Succinylglutamate desuccinylase / Aspartoacylase family
Occurring in:
  1. Aspartoacylase
The deposited structure of PDB entry 2gu2 contains 2 copies of Pfam domain PF04952 (Succinylglutamate desuccinylase / Aspartoacylase family) in Aspartoacylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016708
Domain description: Aspartoacylase
Occurring in:
  1. Aspartoacylase
IPR007036
Domain description: Succinylglutamate desuccinylase/aspartoacylase
Occurring in:
  1. Aspartoacylase

Structure domains

CATH CATH domains
3.40.630.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Zn peptidases
Occurring in:
  1. Aspartoacylase
The deposited structure of PDB entry 2gu2 contains 2 copies of CATH domain 3.40.630.10 (Aminopeptidase) in Aspartoacylase. Showing 1 copy in chain A.
2.20.25.160
Class: Mainly Beta
Architecture: Single Sheet
Topology: N-terminal domain of TfIIb
Homology: N-terminal domain of TfIIb
Occurring in:
  1. Aspartoacylase
The deposited structure of PDB entry 2gu2 contains 2 copies of CATH domain 2.20.25.160 (N-terminal domain of TfIIb) in Aspartoacylase. Showing 1 copy in chain A.
SCOP SCOP annotation
142526
Class: Alpha and beta proteins (a/b)
Fold: Phosphorylase/hydrolase-like
Superfamily: Zn-dependent exopeptidases
Occurring in:
  1. Aspartoacylase
The deposited structure of PDB entry 2gu2 contains 1 copy of SCOP domain 142526 (AstE/AspA-like) in Aspartoacylase. Showing 1 copy in chain A.

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