Function and Biology Details
Reaction catalysed:
(1a) [protein]-N(6)-acetyl-L-lysine + NAD(+) = [protein]-N(6)-(1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl)-L-lysine + nicotinamide
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138136 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NAD-dependent protein deacetylase
Molecule details ›
Chains: A, B
Length: 246 amino acids
Theoretical weight: 27.5 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
Sequence domains: Sir2 family
Structure domains:
Length: 246 amino acids
Theoretical weight: 27.5 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
- Canonical:
Q9WYW0 (Residues: 1-246; Coverage: 100%)
Sequence domains: Sir2 family
Structure domains:
Cellular tumor antigen p53
Molecule details ›
Chains: D, E
Length: 18 amino acids
Theoretical weight: 2.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Length: 18 amino acids
Theoretical weight: 2.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P04637 (Residues: 372-389; Coverage: 5%)
