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Native Crystal Structure of the Isochorismate-Pyruvate Lyase from Pseudomonas aeruginosa

Source organism: Pseudomonas aeruginosa PAO1
Biochemical function: isochorismate pyruvate lyase activity
Biological process: chorismate metabolic process
Cellular component: not assigned

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EC 5.4.99.5: Chorismate mutase

Reaction catalysed:
Chorismate = prephenate
Systematic name:
Chorismate pyruvatemutase
Alternative Name(s):
  • Hydroxyphenylpyruvate synthase

EC 4.2.99.21: Isochorismate lyase

Reaction catalysed:
Isochorismate = salicylate + pyruvate
Systematic name:
Isochorismate pyruvate-lyase (salicylate-forming)
Alternative Name(s):
  • Isochorismate pyruvate lyase
  • Pyochelin biosynthetic protein PchB
  • Salicylate biosynthesis protein pchB

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01817
Domain description: Chorismate mutase type II
Occurring in:
  1. Isochorismate pyruvate lyase
The deposited structure of PDB entry 2h9c contains 2 copies of Pfam domain PF01817 (Chorismate mutase type II) in Isochorismate pyruvate lyase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002701
Domain description: Chorismate mutase II, prokaryotic-type
Occurring in:
  1. Isochorismate pyruvate lyase
IPR008241
Domain description: Salicylate biosynthesis protein PchB
Occurring in:
  1. Isochorismate pyruvate lyase
IPR036979
Domain description: Chorismate mutase domain superfamily
Occurring in:
  1. Isochorismate pyruvate lyase
IPR036263
Domain description: Chorismate mutase type II superfamily
Occurring in:
  1. Isochorismate pyruvate lyase

Structure domain

CATH CATH domain
1.20.59.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Chorismate Mutase Domain, subunit A
Homology: Chorismate mutase
Occurring in:
  1. Isochorismate pyruvate lyase
The deposited structure of PDB entry 2h9c contains 2 copies of CATH domain 1.20.59.10 (Chorismate Mutase Domain, subunit A) in Isochorismate pyruvate lyase. Showing 1 copy in chain A.
SCOP SCOP annotation
48601
Class: All alpha proteins
Fold: Chorismate mutase II
Superfamily: Chorismate mutase II
Occurring in:
  1. Isochorismate pyruvate lyase
The deposited structure of PDB entry 2h9c contains 2 copies of SCOP domain 48601 (Dimeric chorismate mutase) in Isochorismate pyruvate lyase. Showing 1 copy in chain A.

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