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Crystal structure of the selenocysteine to cysteine mutant of human glutathionine peroxidase 2 (GPX2)

Source organism: Homo sapiens
Biochemical function: phospholipid-hydroperoxide glutathione peroxidase activity
Biological process: cellular oxidant detoxification
Cellular component: mitotic spindle

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EC 1.11.1.9: Glutathione peroxidase

Reaction catalysed:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Systematic name:
Glutathione:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • GSH peroxidase
  • Reduced glutathione peroxidase
  • Selenium-glutathione peroxidase

EC 1.11.1.12: Phospholipid-hydroperoxide glutathione peroxidase

Reaction catalysed:
2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H(2)O
Systematic name:
Glutathione:lipid-hydroperoxide oxidoreductase
Alternative Name(s):
  • Hydroperoxide glutathione peroxidase
  • PHGPX
  • Peroxidation-inhibiting protein
  • Peroxidation-inhibiting protein:peroxidase, glutathione (phospholipid hydroperoxide-reducing)
  • Phospholipid hydroperoxide glutathione peroxidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00255
Domain description: Glutathione peroxidase
Occurring in:
  1. Glutathione peroxidase 2
The deposited structure of PDB entry 2he3 contains 1 copy of Pfam domain PF00255 (Glutathione peroxidase) in Glutathione peroxidase 2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000889
Domain description: Glutathione peroxidase
Occurring in:
  1. Glutathione peroxidase 2
IPR029760
Domain description: Glutathione peroxidase conserved site
Occurring in:
  1. Glutathione peroxidase 2
IPR029759
Domain description: Glutathione peroxidase active site
Occurring in:
  1. Glutathione peroxidase 2
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Glutathione peroxidase 2

Structure domain

CATH CATH domain
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. Glutathione peroxidase 2
The deposited structure of PDB entry 2he3 contains 1 copy of CATH domain 3.40.30.10 (Glutaredoxin) in Glutathione peroxidase 2. Showing 1 copy in chain A.

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