2hev

X-ray diffraction
2.41Å resolution

Crystal structure of the complex between OX40L and OX40

Released:
Source organism: Homo sapiens
Primary publication:
The crystal structure of the costimulatory OX40-OX40L complex.
Structure 14 1321-30 (2006)
PMID: 16905106

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-149990 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 4 Chain: F
Molecule details ›
Chain: F
Length: 137 amino acids
Theoretical weight: 15.86 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23510 (Residues: 51-183; Coverage: 73%)
Gene names: TNFSF4, TXGP1
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 4 Chain: R
Molecule details ›
Chain: R
Length: 146 amino acids
Theoretical weight: 15.81 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P43489 (Residues: 29-170; Coverage: 57%)
Gene names: TNFRSF4, TXGP1L
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: R32
Unit cell:
a: 111.903Å b: 111.903Å c: 233.238Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.208 0.251
Expression system: Spodoptera frugiperda