› 2hmh

X-ray diffraction
2Å resolution

Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.

Released:
DOI: 10.2210/pdb2hmh/pdb
Model geometry
Fit model/data
PDB entry 2hmh coloured by chain, front view.
PDB entry 2hmh coloured by chain, side view.
PDB entry 2hmh coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.
Bergamin E, Wu J, Hubbard SR
Structure 14 1285-92 (2006)
PMID: 16905102

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128710 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Suppressor of cytokine signaling 3 Chain: A
Molecule details ›
Chain: A
Length: 152 amino acids
Theoretical weight: 17.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O35718 (Residues: 15-185; Coverage: 66%)
Gene names: Cis3, Cish3, Socs3
Sequence domains: SH2 domain
Structure domains: SH2 domain
Interleukin-6 receptor subunit beta Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.29 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q00560 (Residues: 753-763; Coverage: 1%)
Gene name: Il6st

Ligands and Environments

No bound ligands
2 modified residues:
Ligand CAS 2 x CAS
Ligand PTR 1 x PTR

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2221
Unit cell:
a: 42.918Å b: 94.708Å c: 69.922Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.242 0.291
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

15 review citations

SOCS proteins, cytokine signalling and immune regulation.
Yoshimura et al. (2007)
14 more

11 mentions without citation

The biology and mechanism of action of suppressor of cytokine signaling 3.
Babon et al. (2012)
10 more