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Crystal structure of fragment D from Human Fibrinogen Complexed with Gly-Pro-Arg-Pro-amide.

Source organism: Homo sapiens
Biochemical function: signaling receptor binding
Biological process: protein polymerization
Cellular component: fibrinogen complex

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF08702
Domain description: Fibrinogen alpha/beta chain family
Occurring in:
  1. Fibrinogen alpha chain
  2. Fibrinogen beta chain
  3. Fibrinogen gamma chain
The deposited structure of PDB entry 2hpc contains 4 copies of Pfam domain PF08702 (Fibrinogen alpha/beta chain family) in Fibrinogen alpha chain. Showing 1 copy in chain J.
The deposited structure of PDB entry 2hpc contains 4 copies of Pfam domain PF08702 (Fibrinogen alpha/beta chain family) in Fibrinogen beta chain. Showing 1 copy in chain B.
The deposited structure of PDB entry 2hpc contains 4 copies of Pfam domain PF08702 (Fibrinogen alpha/beta chain family) in Fibrinogen gamma chain. Showing 1 copy in chain C.

PF00147
Domain description: Fibrinogen beta and gamma chains, C-terminal globular domain
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain
The deposited structure of PDB entry 2hpc contains 4 copies of Pfam domain PF00147 (Fibrinogen beta and gamma chains, C-terminal globular domain) in Fibrinogen beta chain. Showing 1 copy in chain B.
The deposited structure of PDB entry 2hpc contains 4 copies of Pfam domain PF00147 (Fibrinogen beta and gamma chains, C-terminal globular domain) in Fibrinogen gamma chain. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR002181
Domain description: Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain
IPR012290
Domain description: Fibrinogen, alpha/beta/gamma chain, coiled coil domain
Occurring in:
  1. Fibrinogen alpha chain
  2. Fibrinogen beta chain
  3. Fibrinogen gamma chain
IPR037579
Domain description: Fibrinogen/angiopoietin-like
Occurring in:
  1. Fibrinogen alpha chain
  2. Fibrinogen beta chain
  3. Fibrinogen gamma chain
IPR020837
Domain description: Fibrinogen, conserved site
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain
IPR014716
Domain description: Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain
IPR036056
Domain description: Fibrinogen-like, C-terminal
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain

Structure domains

CATH CATH domains
3.90.215.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Gamma Fibrinogen; Chain A, domain 1
Homology: Gamma Fibrinogen, chain A, domain 1
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain
The deposited structure of PDB entry 2hpc contains 4 copies of CATH domain 3.90.215.10 (Gamma Fibrinogen; Chain A, domain 1) in Fibrinogen beta chain. Showing 1 copy in chain B.
The deposited structure of PDB entry 2hpc contains 4 copies of CATH domain 3.90.215.10 (Gamma Fibrinogen; Chain A, domain 1) in Fibrinogen gamma chain. Showing 1 copy in chain C.
4.10.530.10
Class: Few Secondary Structures
Architecture: Irregular
Topology: Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2
Homology: Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2
Occurring in:
  1. Fibrinogen beta chain
  2. Fibrinogen gamma chain
The deposited structure of PDB entry 2hpc contains 4 copies of CATH domain 4.10.530.10 (Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2) in Fibrinogen beta chain. Showing 1 copy in chain B.
The deposited structure of PDB entry 2hpc contains 4 copies of CATH domain 4.10.530.10 (Gamma-fibrinogen Carboxyl Terminal Fragment; domain 2) in Fibrinogen gamma chain. Showing 1 copy in chain C.
1.20.5.50
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Homology: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Occurring in:
  1. Fibrinogen alpha chain
  2. Fibrinogen beta chain
The deposited structure of PDB entry 2hpc contains 4 copies of CATH domain 1.20.5.50 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Fibrinogen alpha chain. Showing 1 copy in chain J.
The deposited structure of PDB entry 2hpc contains 4 copies of CATH domain 1.20.5.50 (Single alpha-helices involved in coiled-coils or other helix-helix interfaces) in Fibrinogen beta chain. Showing 1 copy in chain B.
SCOP SCOP annotation
58011
Class: Coiled coil proteins
Fold: Parallel coiled-coil
Superfamily: Fibrinogen coiled-coil and central regions
Occurring in:
  1. Fibrinogen alpha chain
The deposited structure of PDB entry 2hpc contains 4 copies of SCOP domain 58011 (Fibrinogen coiled-coil and central regions) in Fibrinogen alpha chain. Showing 1 copy in chain J.

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