› 2hsp

Solution NMR

SOLUTION STRUCTURE OF THE SH3 DOMAIN OF PHOSPHOLIPASE CGAMMA

Released:
DOI: 10.2210/pdb2hsp/pdb
PDB entry 2hsp coloured by chain, ensemble of 20 models, front view.
PDB entry 2hsp coloured by chain, ensemble of 20 models, side view.
PDB entry 2hsp coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the SH3 domain of phospholipase C-gamma.
Kohda D, Hatanaka H, Odaka M, Mandiyan V, Ullrich A, Schlessinger J, Inagaki F
Cell 72 953-60 (1993)
PMID: 7681365

Function and Biology Details

Reaction catalysed: 
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148516 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Chain: A
Molecule details ›
Chain: A
Length: 71 amino acids
Theoretical weight: 8.25 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P19174 (Residues: 790-852; Coverage: 5%)
Gene names: PLC1, PLCG1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

15 review citations

Protein-protein interactions: methods for detection and analysis.
Phizicky et al. (1995)
14 more

8 mentions without citation

Structure-based conformational preferences of amino acids.
Koehl et al. (1999)
7 more