Function and Biology

The closed ring structure of the Rho transcription termination factor in complex with nucleic acid in the motor domains

Source organism: Escherichia coli
Biochemical function: identical protein binding
Biological process: DNA-templated transcription termination
Cellular component: membrane

Sequence families

Pfam Protein families (Pfam)
PF00006
Domain description: ATP synthase alpha/beta family, nucleotide-binding domain
Occurring in:
  1. Transcription termination factor Rho
The deposited structure of PDB entry 2ht1 contains 2 copies of Pfam domain PF00006 (ATP synthase alpha/beta family, nucleotide-binding domain) in Transcription termination factor Rho. Showing 1 copy in chain D [auth A].

PF07497
Domain description: Rho termination factor, RNA-binding domain
Occurring in:
  1. Transcription termination factor Rho
The deposited structure of PDB entry 2ht1 contains 2 copies of Pfam domain PF07497 (Rho termination factor, RNA-binding domain) in Transcription termination factor Rho. Showing 1 copy in chain D [auth A].

PF07498
Domain description: Rho termination factor, N-terminal domain
Occurring in:
  1. Transcription termination factor Rho
The deposited structure of PDB entry 2ht1 contains 2 copies of Pfam domain PF07498 (Rho termination factor, N-terminal domain) in Transcription termination factor Rho. Showing 1 copy in chain D [auth A].

InterPro InterPro annotations
IPR011113
Domain description: Rho termination factor, RNA-binding domain
Occurring in:
  1. Transcription termination factor Rho
IPR004665
Domain description: Transcription termination factor Rho
Occurring in:
  1. Transcription termination factor Rho
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Transcription termination factor Rho
IPR012340
Domain description: Nucleic acid-binding, OB-fold
Occurring in:
  1. Transcription termination factor Rho
IPR003593
Domain description: AAA+ ATPase domain
Occurring in:
  1. Transcription termination factor Rho
IPR000194
Domain description: ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
Occurring in:
  1. Transcription termination factor Rho
IPR041703
Domain description: Transcription termination factor Rho, ATP binding domain
Occurring in:
  1. Transcription termination factor Rho
IPR011129
Domain description: Cold-shock domain
Occurring in:
  1. Transcription termination factor Rho
IPR011112
Domain description: Rho termination factor-like, N-terminal
Occurring in:
  1. Transcription termination factor Rho
IPR036269
Domain description: Rho termination factor, N-terminal domain superfamily
Occurring in:
  1. Transcription termination factor Rho

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Transcription termination factor Rho
The deposited structure of PDB entry 2ht1 contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Transcription termination factor Rho. Showing 1 copy in chain D [auth A].
2.40.50.140
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: Nucleic acid-binding proteins
Occurring in:
  1. Transcription termination factor Rho
The deposited structure of PDB entry 2ht1 contains 2 copies of CATH domain 2.40.50.140 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Transcription termination factor Rho. Showing 1 copy in chain D [auth A].