› › Function and Biology

Crystal structure of human glutathione peroxidase 5

Source organism: Homo sapiens
Biochemical function: glutathione peroxidase activity
Biological process: cellular oxidant detoxification
Cellular component: extracellular region

Quick links

EC 1.11.1.9: Glutathione peroxidase

Reaction catalysed:
2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O
Systematic name:
Glutathione:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • GSH peroxidase
  • Reduced glutathione peroxidase
  • Selenium-glutathione peroxidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00255
Domain description: Glutathione peroxidase
Occurring in:
  1. Epididymal secretory glutathione peroxidase
The deposited structure of PDB entry 2i3y contains 1 copy of Pfam domain PF00255 (Glutathione peroxidase) in Epididymal secretory glutathione peroxidase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000889
Domain description: Glutathione peroxidase
Occurring in:
  1. Epididymal secretory glutathione peroxidase
IPR029760
Domain description: Glutathione peroxidase conserved site
Occurring in:
  1. Epididymal secretory glutathione peroxidase
IPR029759
Domain description: Glutathione peroxidase active site
Occurring in:
  1. Epididymal secretory glutathione peroxidase
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Epididymal secretory glutathione peroxidase
IPR029068
Domain description: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
Occurring in:
  1. Epididymal secretory glutathione peroxidase

Structure domain

CATH CATH domain
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. Epididymal secretory glutathione peroxidase
The deposited structure of PDB entry 2i3y contains 1 copy of CATH domain 3.40.30.10 (Glutaredoxin) in Epididymal secretory glutathione peroxidase. Showing 1 copy in chain A.

Quick links