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Structures of an Insect Epsilon-class Glutathione S-transferase from the Malaria Vector Anopheles Gambiae: Evidence for High DDT-detoxifying Activity

Source organism: Anopheles gambiae
Biochemical function: glutathione transferase activity
Biological process: glutathione metabolic process
Cellular component: not assigned

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EC 2.5.1.18: Glutathione transferase

Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
  • Glutathione S-alkyl transferase
  • Glutathione S-alkyltransferase
  • Glutathione S-aralkyltransferase
  • Glutathione S-aryltransferase
  • Glutathione S-transferase
  • S-(hydroxyalkyl)glutathione lyase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00043
Domain description: Glutathione S-transferase, C-terminal domain
Occurring in:
  1. glutathione transferase
The deposited structure of PDB entry 2imi contains 2 copies of Pfam domain PF00043 (Glutathione S-transferase, C-terminal domain) in AGAP009194-PA. Showing 1 copy in chain A.

PF13417
Domain description: Glutathione S-transferase, N-terminal domain
Occurring in:
  1. glutathione transferase
The deposited structure of PDB entry 2imi contains 2 copies of Pfam domain PF13417 (Glutathione S-transferase, N-terminal domain) in AGAP009194-PA. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR004045
Domain description: Glutathione S-transferase, N-terminal
Occurring in:
  1. glutathione transferase
IPR004046
Domain description: Glutathione S-transferase, C-terminal
Occurring in:
  1. glutathione transferase
IPR010987
Domain description: Glutathione S-transferase, C-terminal-like
Occurring in:
  1. glutathione transferase
IPR036282
Domain description: Glutathione S-transferase, C-terminal domain superfamily
Occurring in:
  1. glutathione transferase
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. glutathione transferase

Structure domains

CATH CATH domains
1.20.1050.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Homology: Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
Occurring in:
  1. glutathione transferase
The deposited structure of PDB entry 2imi contains 2 copies of CATH domain 1.20.1050.10 (Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2) in AGAP009194-PA. Showing 1 copy in chain A.
3.40.30.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Glutaredoxin
Homology: Glutaredoxin
Occurring in:
  1. glutathione transferase
The deposited structure of PDB entry 2imi contains 2 copies of CATH domain 3.40.30.10 (Glutaredoxin) in AGAP009194-PA. Showing 1 copy in chain A.

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