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Crystal structure of the polygalacturonase from Colletotrichum lupini and its implications for the interaction with polygalacturonase-inhibiting proteins

Source organism: Colletotrichum lupini
Biochemical function: hydrolase activity, acting on glycosyl bonds
Biological process: cell wall organization
Cellular component: extracellular region

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EC 3.2.1.15: Endo-polygalacturonase

Reaction catalysed:
(1,4-alpha-D-galacturonosyl)(n+m) + H(2)O = (1,4-alpha-D-galacturonosyl)(n) + (1,4-alpha-D-galacturonosyl)(m)
Systematic name:
(1->4)-alpha-D-galacturonan glycanohydrolase (endo-cleaving)
Alternative Name(s):
  • Endo-D-galacturonase
  • Endogalacturonase
  • Pectin depolymerase
  • Pectin hydrolase
  • Pectin polygalacturonase
  • Pectinase
  • Pectolase
  • Poly(1,4-alpha-D-galacturonide) glycanohydrolase
  • Poly-alpha-1,4-galacturonide glycanohydrolase
  • Polygalacturonase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00295
Domain description: Glycosyl hydrolases family 28
Occurring in:
  1. endo-polygalacturonase
The deposited structure of PDB entry 2iq7 contains 7 copies of Pfam domain PF00295 (Glycosyl hydrolases family 28) in Endopolygalacturonase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006626
Domain description: Parallel beta-helix repeat
Occurring in:
  1. endo-polygalacturonase
IPR000743
Domain description: Glycoside hydrolase, family 28
Occurring in:
  1. endo-polygalacturonase
IPR011050
Domain description: Pectin lyase fold/virulence factor
Occurring in:
  1. endo-polygalacturonase
IPR012334
Domain description: Pectin lyase fold
Occurring in:
  1. endo-polygalacturonase

Structure domain

CATH CATH domain
2.160.20.10
Class: Mainly Beta
Architecture: 3 Solenoid
Topology: Pectate Lyase C-like
Homology: Single-stranded right-handed beta-helix, Pectin lyase-like
Occurring in:
  1. endo-polygalacturonase
The deposited structure of PDB entry 2iq7 contains 7 copies of CATH domain 2.160.20.10 (Pectate Lyase C-like) in Endopolygalacturonase. Showing 1 copy in chain A.

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