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Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view.

Mackenzie J, Pedersen L, Arent S, Henriksen A
J Biol Chem 281 31012-20 (2006)
Cited: 15 times
EuropePMC logo PMID: 16887802

Abstract

Plants produce a unique peroxisomal short chain-specific acyl-CoA oxidase (ACX4) for beta-oxidation of lipids. The short chain-specific oxidase has little resemblance to other peroxisomal acyl-CoA oxidases but has an approximately 30% sequence identity to mitochondrial acyl-CoA dehydrogenases. Two biochemical features have been linked to structural properties by comparing the structures of short chain-specific Arabidopsis thaliana ACX4 with and without a substrate analogue bound in the active site to known acyl-CoA oxidases and dehydrogenase structures: (i) a solvent-accessible acyl binding pocket is not required for oxygen reactivity, and (ii) the oligomeric state plays a role in substrate pocket architecture but is not linked to oxygen reactivity. The structures indicate that the acyl-CoA oxidases may encapsulate the electrons for transfer to molecular oxygen by blocking the dehydrogenase substrate interaction site with structural extensions. A small binding pocket observed adjoining the flavin adenine dinucleotide N5 and C4a atoms could increase the number of productive encounters between flavin adenine dinucleotide and O2.

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  1. Alteration of Electron Acceptor Preferences in the Oxidative Half-Reaction of Flavin-Dependent Oxidases and Dehydrogenases. Hiraka K, Tsugawa W, Sode K. Int J Mol Sci 21 E3797 (2020)

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  3. Probing the effects of streptomycin on Brassica napus germination and assessing its molecular interactions using extensive molecular dynamics (MD) simulations. Patel R, Prajapati K, Goswami D, Saraf M. Sci Rep 13 19066 (2023)


Reviews citing this publication (4)

  1. Seed storage oil mobilization. Graham IA. Annu Rev Plant Biol 59 115-142 (2008)
  2. Beta-oxidation in fatty acid degradation and beyond. Goepfert S, Poirier Y. Curr Opin Plant Biol 10 245-251 (2007)
  3. Structure and function of plant acyl-CoA oxidases. Arent S, Pye VE, Henriksen A. Plant Physiol Biochem 46 292-301 (2008)
  4. Cystic fibrosis-related oxidative stress and intestinal lipid disorders. Kleme ML, Levy E. Antioxid Redox Signal 22 614-631 (2015)

Articles citing this publication (7)

  1. IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response. Zolman BK, Nyberg M, Bartel B. Plant Mol Biol 64 59-72 (2007)
  2. Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria. Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD. Free Radic Biol Med 61 298-309 (2013)
  3. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Zhang X, Li K, Jones RA, Bruner SD, Butcher RA. Proc Natl Acad Sci U S A 113 10055-10060 (2016)
  4. Mechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase. Fitzpatrick PF, Bozinovski DM, Héroux A, Shaw PG, Valley MP, Orville AM. Biochemistry 46 13800-13808 (2007)
  5. Structure of the prolyl-acyl carrier protein oxidase involved in the biosynthesis of the cyanotoxin anatoxin-a. Moncoq K, Regad L, Mann S, Méjean A, Ploux O. Acta Crystallogr D Biol Crystallogr 69 2340-2352 (2013)
  6. Molecular Basis for Converting (2S)-Methylsuccinyl-CoA Dehydrogenase into an Oxidase. Burgener S, Schwander T, Romero E, Fraaije MW, Erb TJ. Molecules 23 E68 (2017)
  7. Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family. Schwander T, McLean R, Zarzycki J, Erb TJ. J Biol Chem 293 1702-1712 (2018)


Related citations provided by authors (2)

  1. Expression, purification and crystallization of two peroxisomal acyl-CoA oxidases from Arabidopsis thaliana.. Pedersen L, Henriksen A Acta Crystallogr D Biol Crystallogr 60 1125-8 (2004)
  2. Arabidopsis mutants in short- and medium-chain acyl-CoA oxidase activities accumulate acyl-CoAs and reveal that fatty acid beta-oxidation is essential for embryo development.. Rylott EL, Rogers CA, Gilday AD, Edgell T, Larson TR, Graham IA J Biol Chem 278 21370-7 (2003)

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