› 2j15

Solution NMR

Cyclic MrIA: An exceptionally stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter.

Released:
DOI: 10.2210/pdb2j15/pdb
PDB entry 2j15 coloured by chain, ensemble of 21 models, front view.
PDB entry 2j15 coloured by chain, ensemble of 21 models, side view.
PDB entry 2j15 coloured by chain, ensemble of 21 models, top view.
Source organism: Conus marmoreus
Primary publication:
Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter.
Lovelace ES, Armishaw CJ, Colgrave ML, Wahlstrom ME, Alewood PF, Daly NL, Craik DJ
J Med Chem 49 6561-8 (2006)
PMID: 17064074

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157729 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chi-conotoxin MrIA Chain: A
Molecule details ›
Chain: A
Length: 15 amino acids
Theoretical weight: 1.54 KDa
Source organism: Conus marmoreus
Expression system: Not provided
UniProt:
  • Canonical: P58808 (Residues: 49-61; Coverage: 31%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING, RESTRAINED MOLECULAR DYNAMICS, WATERGATE
Expression system: Not provided

Quick links

Citations

20 review citations

Natural products to drugs: natural product-derived compounds in clinical trials.
Butler MS. (2008)
19 more

3 mentions without citation

Discovery, synthesis, and structure-activity relationships of conotoxins.
Akondi et al. (2014)
2 more