Function and Biology

1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE FROM THERMUS THERMOPHIRUS WITH BOUND INHIBITOR GLYCINE AND NAD.

EC 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase

Reaction catalysed:
L-glutamate 5-semialdehyde + NAD(+) + H(2)O = L-glutamate + NADH
Systematic name:
L-glutamate gamma-semialdehyde:NAD(+) oxidoreductase
Alternative Name(s):
  • 1-pyrroline dehydrogenase
  • 1-pyrroline-5-carboxylate dehydrogenase
  • 1-pyrroline-5-carboxylate:NAD(+) oxidoreductase
  • Delta(1)-pyrroline-5-carboxylate dehydrogenase
  • Delta(1)-pyrroline-5-carboxylic acid dehydrogenase
  • L-pyrroline-5-carboxylate-NAD(+) oxidoreductase
  • Pyrroline-5-carboxylate dehydrogenase
  • Pyrroline-5-carboxylic acid dehydrogenase

Sequence family

Pfam Protein family (Pfam)
PF00171
Domain description: Aldehyde dehydrogenase family
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
The deposited structure of PDB entry 2j5n contains 2 copies of Pfam domain PF00171 (Aldehyde dehydrogenase family) in L-glutamate gamma-semialdehyde dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016160
Domain description: Aldehyde dehydrogenase, cysteine active site
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
IPR016163
Domain description: Aldehyde dehydrogenase, C-terminal
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
IPR029510
Domain description: Aldehyde dehydrogenase, glutamic acid active site
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
IPR015590
Domain description: Aldehyde dehydrogenase domain
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
IPR016162
Domain description: Aldehyde dehydrogenase, N-terminal
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
IPR005932
Domain description: 1-pyrroline-5-carboxylate dehydrogenase
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
IPR016161
Domain description: Aldehyde/histidinol dehydrogenase
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase

Structure domains

CATH CATH domains
3.40.605.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 1
Homology: Aldehyde Dehydrogenase; Chain A, domain 1
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
The deposited structure of PDB entry 2j5n contains 2 copies of CATH domain 3.40.605.10 (Aldehyde Dehydrogenase; Chain A, domain 1) in L-glutamate gamma-semialdehyde dehydrogenase. Showing 1 copy in chain A.
3.40.309.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aldehyde Dehydrogenase; Chain A, domain 2
Homology: Aldehyde Dehydrogenase; Chain A, domain 2
Occurring in:
  1. L-glutamate gamma-semialdehyde dehydrogenase
The deposited structure of PDB entry 2j5n contains 2 copies of CATH domain 3.40.309.10 (Aldehyde Dehydrogenase; Chain A, domain 2) in L-glutamate gamma-semialdehyde dehydrogenase. Showing 1 copy in chain A.