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Structure of the monooxygenase component of p-hydroxyphenylacetate hydroxylase from Acinetobacter baumannii

Source organism: Acinetobacter baumannii
Biochemical function: 4-hydroxyphenylacetate 3-monooxygenase activity
Biological process: fatty acid beta-oxidation using acyl-CoA dehydrogenase
Cellular component: cytoplasm

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EC 1.14.14.9: 4-hydroxyphenylacetate 3-monooxygenase

Reaction catalysed:
4-hydroxyphenylacetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(2)O
Systematic name:
4-hydroxyphenylacetate,FAD:oxygen oxidoreductase (3-hydroxylating)
Alternative Name(s):
  • 4 HPA 3-hydroxylase
  • 4-hydroxyphenylacetic acid-3-hydroxylase
  • HpaB
  • p-hydroxyphenylacetate 3-hydroxylase
  • p-hydroxyphenylacetate 3-hydroxylase (FAD)
  • p-hydroxyphenylacetate hydroxylase
  • p-hydroxyphenylacetate hydroxylase (FAD)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF08028
Domain description: Acyl-CoA dehydrogenase, C-terminal domain
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
The deposited structure of PDB entry 2jbs contains 4 copies of Pfam domain PF08028 (Acyl-CoA dehydrogenase, C-terminal domain) in p-hydroxyphenylacetate 3-hydroxylase, oxygenase component. Showing 1 copy in chain C.

PF02771
Domain description: Acyl-CoA dehydrogenase, N-terminal domain
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
The deposited structure of PDB entry 2jbs contains 4 copies of Pfam domain PF02771 (Acyl-CoA dehydrogenase, N-terminal domain) in p-hydroxyphenylacetate 3-hydroxylase, oxygenase component. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR013107
Domain description: Acyl-CoA dehydrogenase, C-terminal domain
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
IPR036250
Domain description: Acyl-CoA dehydrogenase-like, C-terminal
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
IPR046373
Domain description: Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
IPR009100
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
IPR037069
Domain description: Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component

Structure domains

CATH CATH domains
1.20.140.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 3
Homology: Butyryl-CoA Dehydrogenase, subunit A, domain 3
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
The deposited structure of PDB entry 2jbs contains 4 copies of CATH domain 1.20.140.10 (Butyryl-CoA Dehydrogenase, subunit A; domain 3) in p-hydroxyphenylacetate 3-hydroxylase, oxygenase component. Showing 1 copy in chain C.
2.40.110.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Butyryl-CoA Dehydrogenase, subunit A; domain 2
Homology: Butyryl-CoA Dehydrogenase, subunit A, domain 2
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
The deposited structure of PDB entry 2jbs contains 4 copies of CATH domain 2.40.110.10 (Butyryl-CoA Dehydrogenase, subunit A; domain 2) in p-hydroxyphenylacetate 3-hydroxylase, oxygenase component. Showing 1 copy in chain C.
1.10.540.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Butyryl-Coa Dehydrogenase, subunit A; domain 1
Homology: Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Occurring in:
  1. p-hydroxyphenylacetate 3-hydroxylase, oxygenase component
The deposited structure of PDB entry 2jbs contains 4 copies of CATH domain 1.10.540.10 (Butyryl-Coa Dehydrogenase, subunit A; domain 1) in p-hydroxyphenylacetate 3-hydroxylase, oxygenase component. Showing 1 copy in chain C.

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