› 2jdg

X-ray diffraction
2Å resolution

Affilin based on HUMAN GAMMA-B CRYSTALLIN

Released:
DOI: 10.2210/pdb2jdg/pdb
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PDB entry 2jdg coloured by chain, front view.
PDB entry 2jdg coloured by chain, side view.
PDB entry 2jdg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein.
Ebersbach H, Fiedler E, Scheuermann T, Fiedler M, Stubbs MT, Reimann C, Proetzel G, Rudolph R, Fiedler U
J Mol Biol 372 172-85 (2007)
PMID: 17628592

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Gamma-crystallin B Chain: A
Molecule details ›
Chain: A
Length: 183 amino acids
Theoretical weight: 21.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07316 (Residues: 1-175; Coverage: 100%)
Gene names: CRYG2, CRYGB
Sequence domains: Beta/Gamma crystallin
Structure domains: Crystallins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P212121
Unit cell:
a: 47.72Å b: 53.95Å c: 62.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.275
Expression system: Escherichia coli

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Citations

10 review citations

Engineered protein scaffolds as next-generation antibody therapeutics.
Gebauer et al. (2009)
9 more

3 mentions without citation

Peptide aptamers: development and applications.
Reverdatto et al. (2015)
2 more

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