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STRUCTURAL AND MECHANISTIC BASIS OF PENICILLIN BINDING PROTEIN INHIBITION BY LACTIVICINS

Source organism: Streptococcus pneumoniae R6
Biochemical function: penicillin binding
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00905
Domain description: Penicillin binding protein transpeptidase domain
Occurring in:
  1. peptidoglycan glycosyltransferase
The deposited structure of PDB entry 2je5 contains 2 copies of Pfam domain PF00905 (Penicillin binding protein transpeptidase domain) in peptidoglycan glycosyltransferase. Showing 1 copy in chain B.

PF00912
Domain description: Transglycosylase
Occurring in:
  1. peptidoglycan glycosyltransferase
The deposited structure of PDB entry 2je5 contains 2 copies of Pfam domain PF00912 (Transglycosylase) in peptidoglycan glycosyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR012338
Domain description: Beta-lactamase/transpeptidase-like
Occurring in:
  1. peptidoglycan glycosyltransferase
IPR001460
Domain description: Penicillin-binding protein, transpeptidase
Occurring in:
  1. peptidoglycan glycosyltransferase
IPR036950
Domain description: Penicillin binding protein transglycosylase domain
Occurring in:
  1. peptidoglycan glycosyltransferase
IPR001264
Domain description: Glycosyl transferase, family 51
Occurring in:
  1. peptidoglycan glycosyltransferase
IPR023346
Domain description: Lysozyme-like domain superfamily
Occurring in:
  1. peptidoglycan glycosyltransferase

Structure domains

CATH CATH domains
3.40.710.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Beta-lactamase
Homology: DD-peptidase/beta-lactamase superfamily
Occurring in:
  1. peptidoglycan glycosyltransferase
The deposited structure of PDB entry 2je5 contains 2 copies of CATH domain 3.40.710.10 (Beta-lactamase) in peptidoglycan glycosyltransferase. Showing 1 copy in chain B.
3.90.1310.40
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Penicillin-binding protein 2a (Domain 2)
Homology: Penicillin-binding protein 2a (Domain 2)
Occurring in:
  1. peptidoglycan glycosyltransferase
The deposited structure of PDB entry 2je5 contains 2 copies of CATH domain 3.90.1310.40 (Penicillin-binding protein 2a (Domain 2)) in peptidoglycan glycosyltransferase. Showing 1 copy in chain B.
3.40.50.12800
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. peptidoglycan glycosyltransferase
The deposited structure of PDB entry 2je5 contains 2 copies of CATH domain 3.40.50.12800 (Rossmann fold) in peptidoglycan glycosyltransferase. Showing 1 copy in chain B.

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