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Solution Structure of the Ring Domain of Human TRAF6

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor binding
Biological process: protein ubiquitination
Cellular component: not assigned

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EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF13923
Domain description: Zinc finger, C3HC4 type (RING finger)
Occurring in:
  1. TNF receptor-associated factor 6
The deposited structure of PDB entry 2jmd contains 1 copy of Pfam domain PF13923 (Zinc finger, C3HC4 type (RING finger)) in TNF receptor-associated factor 6. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001841
Domain description: Zinc finger, RING-type
Occurring in:
  1. TNF receptor-associated factor 6
IPR017907
Domain description: Zinc finger, RING-type, conserved site
Occurring in:
  1. TNF receptor-associated factor 6
IPR027139
Domain description: TNF receptor-associated factor 6, C3HC3D-type RING zinc finger
Occurring in:
  1. TNF receptor-associated factor 6
IPR013083
Domain description: Zinc finger, RING/FYVE/PHD-type
Occurring in:
  1. TNF receptor-associated factor 6

Structure domain

CATH CATH domain
3.30.40.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Herpes Virus-1
Homology: Zinc/RING finger domain, C3HC4 (zinc finger)
Occurring in:
  1. TNF receptor-associated factor 6
The deposited structure of PDB entry 2jmd contains 1 copy of CATH domain 3.30.40.10 (Herpes Virus-1) in TNF receptor-associated factor 6. Showing 1 copy in chain A.

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