› 2jpw

Solution NMR

Solution structure of the bisphosphorylated cardiac specific N-extension of cardiac troponin I

Released:
DOI: 10.2210/pdb2jpw/pdb
PDB entry 2jpw coloured by chain, ensemble of 20 models, front view.
PDB entry 2jpw coloured by chain, ensemble of 20 models, side view.
PDB entry 2jpw coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin.
Howarth JW, Meller J, Solaro RJ, Trewhella J, Rosevear PR
J Mol Biol 373 706-22 (2007)
PMID: 17854829

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155811 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin I, cardiac muscle Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.56 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P48787 (Residues: 1-32; Coverage: 15%)
Gene name: Tnni3
Sequence domains: Troponin I residues 1-32

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links

Citations

19 review citations

Thin filament mutations: developing an integrative approach to a complex disorder.
Tardiff JC. (2011)
18 more

5 mentions without citation

Molecular effects of familial hypertrophic cardiomyopathy-related mutations in the TNT1 domain of cTnT.
Manning et al. (2012)
4 more