› 2jxz

Solution NMR

Solution Conformation of A Non-Amyloidogenic Analogue of Human Calcitonin in Sodium Dodecyl Sulfate Micelles

Released:
DOI: 10.2210/pdb2jxz/pdb
PDB entry 2jxz coloured by chain, ensemble of 20 models, front view.
PDB entry 2jxz coloured by chain, ensemble of 20 models, side view.
PDB entry 2jxz coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Converting the highly amyloidogenic human calcitonin into a powerful fibril inhibitor by three-dimensional structure homology with a non-amyloidogenic analogue.
Andreotti G, Vitale RM, Avidan-Shpalter C, Amodeo P, Gazit E, Motta A
J Biol Chem 286 2707-18 (2011)
PMID: 21078667

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134133 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcitonin Chain: A
Molecule details ›
Chain: A
Length: 33 amino acids
Theoretical weight: 3.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01258 (Residues: 85-116; Coverage: 28%)
Gene names: CALC1, CALCA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Restrained Simulated Annealing/Energy Minimization
Expression system: Not provided

Quick links

Citations

1 review citation

Protein folding and aggregation into amyloid: the interference by natural phenolic compounds.
Stefani et al. (2013)
15 other articles

5 mentions without citation

Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?
Barwell et al. (2012)
4 more