EC 2.7.11.18: Myosin-light-chain kinase
Reaction catalysed:
ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate
Systematic name:
ATP:[myosin-light-chain] O-phosphotransferase
Alternative Name(s):
- ATP:myosin-light-chain O-phosphotransferase
- Calcium/calmodulin-dependent myosin light chain kinase
- MLCK
- MLCkase
- Myosin kinase
- Myosin light chain kinase
- Myosin light chain protein kinase
- Myosin light-chain kinase
- Myosin light-chain kinase (phosphorylating)
- STK18
- Smooth-muscle-myosin-light-chain kinase
- [Myosin-light-chain] kinase
GO terms
Biochemical function:
- transporter inhibitor activity
- protein phosphatase activator activity
- calcium-dependent protein binding
- metal ion binding
- transmembrane transporter binding
- protein serine/threonine kinase activator activity
- titin binding
- protein kinase binding
- calcium channel inhibitor activity
- adenylate cyclase activator activity
- protein binding
- calcium ion binding
- calcium channel regulator activity
Biological process:
- mitochondrion-endoplasmic reticulum membrane tethering
- negative regulation of calcium ion export across plasma membrane
- regulation of cell communication by electrical coupling involved in cardiac conduction
- negative regulation of high voltage-gated calcium channel activity
- presynaptic endocytosis
- organelle localization by membrane tethering
- regulation of cardiac muscle cell action potential
- calcineurin-mediated signaling
- cellular response to type II interferon
- negative regulation of ryanodine-sensitive calcium-release channel activity
- regulation of ryanodine-sensitive calcium-release channel activity
- long-term synaptic potentiation
- regulation of cardiac muscle contraction
- response to calcium ion
- regulation of calcium-mediated signaling
- positive regulation of receptor signaling pathway via JAK-STAT
- cellular response to interferon-beta
- regulation of cytokinesis
- substantia nigra development
- autophagosome membrane docking
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- G protein-coupled receptor signaling pathway
- detection of calcium ion
- regulation of heart rate
- G2/M transition of mitotic cell cycle
Cellular component:
- catalytic complex
- presynaptic cytosol
- sperm midpiece
- calyx of Held
- myelin sheath
- cell projection
- calcium channel complex
- protein-containing complex
- vesicle
- motile cilium
- sarcomere
- membrane
- voltage-gated potassium channel complex
- cilium
- plasma membrane
- spindle microtubule
- cytoskeleton
- cytosol
- spindle
- centrosome
- cytoplasm
- nucleoplasm
- nucleus
- extracellular region
- spindle pole
Protein family (Pfam)
InterPro annotations
SCOP annotation