Function and Biology Details
Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
3'-end directed exonucleolytic cleavage of viral RNA-DNA hybrid
Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Endopeptidase for which the P1 residue is preferably hydrophobic.
Biochemical function:
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Integrase (preferred)
PDBe Complex ID:
PDB-CPX-137997 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrix protein p17
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.9 KDa
Source organism: Human immunodeficiency virus type 2 (ISOLATE ROD)
Expression system: Escherichia coli
UniProt:
Sequence domains: gag gene protein p17 (matrix protein)
Structure domains: Immunodeficiency lentiviruses, gag gene matrix protein p17
Length: 134 amino acids
Theoretical weight: 14.9 KDa
Source organism: Human immunodeficiency virus type 2 (ISOLATE ROD)
Expression system: Escherichia coli
UniProt:
- Canonical:
P04584 (Residues: 2-135; Coverage: 9%)
Sequence domains: gag gene protein p17 (matrix protein)
Structure domains: Immunodeficiency lentiviruses, gag gene matrix protein p17
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
wwPDB Validation report is not available for this NMR entry.
Refinement method:
distance geometry
Expression system: Escherichia coli
