› › Function and Biology

Deletions in a surface loop divert the folding of a protein domain into a metastable dimeric form

Source organism: Escherichia coli K-12
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

Quick links

EC 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase

Reaction catalysed:
Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine
Systematic name:
Acetyl-CoA:enzyme-N(6)-(dihydrolipoyl)lysine S-acetyltransferase
Alternative Name(s):
  • Acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase
  • Acetyl-CoA:dihydrolipoamide S-acetyltransferase
  • Dihydrolipoamide S-acetyltransferase
  • Dihydrolipoate acetyltransferase
  • Dihydrolipoic transacetylase
  • Dihydrolipoyl acetyltransferase
  • Enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase
  • Lipoate acetyltransferase
  • Lipoate transacetylase
  • Lipoic acetyltransferase
  • Lipoic acid acetyltransferase
  • Lipoic transacetylase
  • Lipoylacetyltransferase
  • Thioltransacetylase A
  • Transacetylase X

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00364
Domain description: Biotin-requiring enzyme
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
The deposited structure of PDB entry 2k7v contains 2 copies of Pfam domain PF00364 (Biotin-requiring enzyme) in Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000089
Domain description: Biotin/lipoyl attachment
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR003016
Domain description: 2-oxo acid dehydrogenase, lipoyl-binding site
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR011053
Domain description: Single hybrid motif
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Structure domains

CATH CATH domains
6.20.100.10
Class: Special
Architecture: Other non-globular
Topology: Actin; Chain A, domain 2
Homology: Actin; Chain A, domain 2
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
The deposited structure of PDB entry 2k7v contains 1 copy of CATH domain 6.20.100.10 (Actin; Chain A, domain 2) in Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. Showing 1 copy in chain B.
2.40.50.100
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
The deposited structure of PDB entry 2k7v contains 1 copy of CATH domain 2.40.50.100 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. Showing 1 copy in chain A.

Quick links