› 2ka9

Solution NMR

Solution structure of PSD-95 PDZ12 complexed with cypin peptide

Released:
DOI: 10.2210/pdb2ka9/pdb
PDB entry 2ka9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ka9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ka9 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Creating conformational entropy by increasing interdomain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95.
Wang W, Weng J, Zhang X, Liu M, Zhang M
J Am Chem Soc 131 787-96 (2009)
PMID: 19072119

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151882 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disks large homolog 4 Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 20.13 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
cypin peptide Chains: B, C
Molecule details ›
Chains: B, C
Length: 9 amino acids
Theoretical weight: 949 Da
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

7 review citations

Regulation of AMPA receptor surface diffusion by PSD-95 slots.
Opazo et al. (2012)
6 more

7 mentions without citation

PDZ Domains as Drug Targets.
Christensen et al. (2019)
6 more