› 2kc9

Solution NMR

Structure of E. coli toxin RelE (R81A/R83A) mutant in the free state

Released:
DOI: 10.2210/pdb2kc9/pdb
PDB entry 2kc9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2kc9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2kc9 coloured by chain, ensemble of 20 models, top view.
Source organism: Escherichia coli K-12
Primary publication:
Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site.
Li GY, Zhang Y, Inouye M, Ikura M
J Biol Chem 284 14628-36 (2009)
PMID: 19297318

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142866 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
mRNA interferase toxin RelE Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 11.36 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C077 (Residues: 1-95; Coverage: 100%)
Gene names: JW1555, b1563, relE
Sequence domains: ParE toxin of type II toxin-antitoxin system, parDE
Structure domains: RelE-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Toxin-antitoxin systems in bacteria and archaea.
Yamaguchi et al. (2011)
15 more

4 mentions without citation

Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy.
Coussens et al. (2016)
3 more