› 2kft

Solution NMR

NMR Solution structure of the first PHD finger domain of human Autoimmune Regulator (AIRE) in complex with Histone H3(1-20Cys) Peptide

Released:
DOI: 10.2210/pdb2kft/pdb
PDB entry 2kft coloured by chain, ensemble of 20 models, front view.
PDB entry 2kft coloured by chain, ensemble of 20 models, side view.
PDB entry 2kft coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator.
Chakravarty S, Zeng L, Zhou MM
Structure 17 670-9 (2009)
PMID: 19446523

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129169 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Autoimmune regulator Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43918 (Residues: 294-347; Coverage: 10%)
Gene names: AIRE, APECED
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)
Histone H3 Chain: B
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.29 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

18 review citations

The PHD finger: a versatile epigenome reader.
Sanchez et al. (2011)
17 more

10 mentions without citation

PHD fingers: epigenetic effectors and potential drug targets.
Musselman et al. (2009)
9 more