Function and Biology

NMR based structural model of the UBCH8-UBIQUITIN complex

Source organism: Homo sapiens
Biochemical function: ubiquitin conjugating enzyme activity
Biological process: innate immune response
Cellular component: cytosol

EC 2.3.2.23: E2 ubiquitin-conjugating enzyme

Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
  • UBC
  • Ubiquitin-carrier-protein E2
  • Ubiquitin-conjugating enzyme E2

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 2kjh contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Ubiquitin. Showing 1 copy in chain B.

PF00179
Domain description: Ubiquitin-conjugating enzyme
Occurring in:
  1. Ubiquitin/ISG15-conjugating enzyme E2 L6
The deposited structure of PDB entry 2kjh contains 1 copy of Pfam domain PF00179 (Ubiquitin-conjugating enzyme) in Ubiquitin/ISG15-conjugating enzyme E2 L6. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin
IPR000608
Domain description: Ubiquitin-conjugating enzyme E2
Occurring in:
  1. Ubiquitin/ISG15-conjugating enzyme E2 L6
IPR016135
Domain description: Ubiquitin-conjugating enzyme/RWD-like
Occurring in:
  1. Ubiquitin/ISG15-conjugating enzyme E2 L6
IPR019954
Domain description: Ubiquitin conserved site
Occurring in:
  1. Ubiquitin
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin
IPR023313
Domain description: Ubiquitin-conjugating enzyme, active site
Occurring in:
  1. Ubiquitin/ISG15-conjugating enzyme E2 L6

Structure domains

CATH CATH domains
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin
The deposited structure of PDB entry 2kjh contains 1 copy of CATH domain 3.10.20.90 (Ubiquitin-like (UB roll)) in Ubiquitin. Showing 1 copy in chain B.
3.10.110.10
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin Conjugating Enzyme
Homology: Ubiquitin Conjugating Enzyme
Occurring in:
  1. Ubiquitin/ISG15-conjugating enzyme E2 L6
The deposited structure of PDB entry 2kjh contains 1 copy of CATH domain 3.10.110.10 (Ubiquitin Conjugating Enzyme) in Ubiquitin/ISG15-conjugating enzyme E2 L6. Showing 1 copy in chain A.