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Dynamics of insulin probed by 1H-NMR amide proton exchange anomalous flexibility of the receptor-binding surface

Solution NMR
PDB entry 2kjj coloured by chain, ensemble of 20 models, front view.
PDB entry 2kjj coloured by chain, ensemble of 20 models, side view.
PDB entry 2kjj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin complex
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Multimeric state: hetero dimer
Accessible surface area: 3667.18 Å2
Buried surface area: 1463.26 Å2
Dissociation area: 731.63 Å2
Dissociation energy (ΔGdiss): 10.59 kcal/mol
Dissociation entropy (TΔSdiss): 8.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134182
Complex Portal ID: CPX-943

Macromolecules

Insulin A chain
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
InterPro:
Insulin A chain in PDB entry 2kjj, assembly 1, front view.
Insulin A chain in PDB entry 2kjj, assembly 1, side view.
Insulin A chain in PDB entry 2kjj, assembly 1, top view.
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Insulin B chain
Chain: B
Length: 30 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Pfam: Insulin/IGF/Relaxin family
InterPro:
Insulin B chain in PDB entry 2kjj, assembly 1, front view.
Insulin B chain in PDB entry 2kjj, assembly 1, side view.
Insulin B chain in PDB entry 2kjj, assembly 1, top view.
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