› 2kqn

Solution NMR

Solution structure of the AL-09 H87Y immunoglobulin light chain variable domain

Released:
DOI: 10.2210/pdb2kqn/pdb
PDB entry 2kqn coloured by chain, ensemble of 20 models, front view.
PDB entry 2kqn coloured by chain, ensemble of 20 models, side view.
PDB entry 2kqn coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
A single mutation promotes amyloidogenicity through a highly promiscuous dimer interface.
Peterson FC, Baden EM, Owen BA, Volkman BF, Ramirez-Alvarado M
Structure 18 563-70 (2010)
PMID: 20462490

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213160 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ig kappa chain V-I region AU Chains: A, B
Molecule details ›
Chains: A, B
Length: 110 amino acids
Theoretical weight: 12.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: AUTOMATED METHODS WERE USED FOR BACKBONE CHEMICAL SHIFT ASSIGNMENT AND ITERATIVE NOE REFINEMENT. FINAL STRUCTURES WERE OBTAINED BY MOLECULAR DYNAMICS IN EXPLICIT SOLVENT
Expression system: Escherichia coli

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Citations

3 review citations

Current perspectives on cardiac amyloidosis.
Guan et al. (2012)
2 more

4 mentions without citation

Systemic amyloidoses.
Blancas-Mejía et al. (2013)
3 more