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Solution Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of cardiac Troponin I and W7

Solution NMR
PDB entry 2krd coloured by chain, ensemble of 20 models, front view.
PDB entry 2krd coloured by chain, ensemble of 20 models, side view.
PDB entry 2krd coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Troponin C, slow skeletal and cardiac muscles and Troponin I, cardiac muscle
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Multimeric state: hetero dimer
Accessible surface area: 7005.74 Å2
Buried surface area: 1934.61 Å2
Dissociation area: 711.14 Å2
Dissociation energy (ΔGdiss): 6.7 kcal/mol
Dissociation entropy (TΔSdiss): 8.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148574

Macromolecules

Troponin C, slow skeletal and cardiac muscles
Chain: C
Length: 89 amino acids
Theoretical weight: 10.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
Gene names: TNNC, TNNC1
Pfam: EF-hand domain pair
InterPro:
Troponin C, slow skeletal and cardiac muscles in PDB entry 2krd, assembly 1, front view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 2krd, assembly 1, side view.
Troponin C, slow skeletal and cardiac muscles in PDB entry 2krd, assembly 1, top view.
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Troponin I, cardiac muscle
Chain: I
Length: 17 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P19429 (Residues: 148-164; Coverage: 8%)
Gene names: TNNC1, TNNI3
Troponin I, cardiac muscle in PDB entry 2krd, assembly 1, front view.
Troponin I, cardiac muscle in PDB entry 2krd, assembly 1, side view.
Troponin I, cardiac muscle in PDB entry 2krd, assembly 1, top view.
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