› 2kuo

Solution NMR

Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response

Released:
DOI: 10.2210/pdb2kuo/pdb
PDB entry 2kuo coloured by chain, ensemble of 20 models, front view.
PDB entry 2kuo coloured by chain, ensemble of 20 models, side view.
PDB entry 2kuo coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Li GY, McCulloch RD, Fenton A, Cheung M, Meng L, Ikura M, Koch CA

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-568929 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aprataxin and PNK-like factor Chain: A
Molecule details ›
Chain: A
Length: 91 amino acids
Theoretical weight: 10.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IW19 (Residues: 360-448; Coverage: 17%)
Gene names: APLF, C2orf13, PALF, XIP1
Sequence domains: PBZ domain

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

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