› 2kvy

Solution NMR

NMR solution structure of the 4:1 complex between an uncharged distamycin A analogue and [d(TGGGGT)]4

Released:
DOI: 10.2210/pdb2kvy/pdb
PDB entry 2kvy coloured by chain, ensemble of 10 models, front view.
PDB entry 2kvy coloured by chain, ensemble of 10 models, side view.
PDB entry 2kvy coloured by chain, ensemble of 10 models, top view.
Source organism: Synthetic construct
Primary publication:
Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.
Cosconati S, Marinelli L, Trotta R, Virno A, De Tito S, Romagnoli R, Pagano B, Limongelli V, Giancola C, Baraldi PG, Mayol L, Novellino E, Randazzo A
J Am Chem Soc 132 6425-33 (2010)
PMID: 20394365

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115506 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
DNA (5'-D(*TP*GP*GP*GP*GP*T)-3') Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 6 nucleotides
Theoretical weight: 1.88 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand KVY 4 x KVY
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

8 review citations

The application of DNA and RNA G-quadruplexes to therapeutic medicines.
Collie et al. (2011)
7 more

3 mentions without citation

Major Achievements in the Design of Quadruplex-Interactive Small Molecules.
Mendes et al. (2022)
2 more