› 2l6f

Solution NMR

NMR Solution structure of FAT domain of FAK complexed with LD2 and LD4 motifs of PAXILLIN

Released:
DOI: 10.2210/pdb2l6f/pdb
PDB entry 2l6f coloured by chain, ensemble of 20 models, front view.
PDB entry 2l6f coloured by chain, ensemble of 20 models, side view.
PDB entry 2l6f coloured by chain, ensemble of 20 models, top view.
Source organism: Gallus gallus
Entry authors: Bertolucci CM, Guibao C, Zhang C, Zheng J

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155842 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1; Paxillin Chain: A
Molecule details ›
Chain: A
Length: 215 amino acids
Theoretical weight: 22.25 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q00944 (Residues: 916-1053; Coverage: 13%)
  • Canonical: P49024 (Residues: 140-161; Coverage: 4%)
Gene names: FAK, FAK1, PTK2, PXN
Sequence domains: Focal adhesion targeting region
Structure domains: Nucleotidyltransferases domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli BL21

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