› 2l8w

Solution NMR

r(CCGCUGCGG)2 UU Internal Loop Found in Myotonic Dystrophy Type 1 - UU pair with two hydrogen bond pairs

Released:
DOI: 10.2210/pdb2l8w/pdb
PDB entry 2l8w coloured by chain, front view.
PDB entry 2l8w coloured by chain, side view.
PDB entry 2l8w coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
NMR spectroscopy and molecular dynamics simulation of r(CCGCUGCGG)₂ reveal a dynamic UU internal loop found in myotonic dystrophy type 1.
Parkesh R, Fountain M, Disney MD
Biochemistry 50 599-601 (2011)
PMID: 21204525

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196455 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*CP*CP*GP*CP*UP*GP*CP*GP*G)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 9 nucleotides
Theoretical weight: 2.86 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 14%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

3 review citations

RNA Structures as Mediators of Neurological Diseases and as Drug Targets.
Bernat et al. (2015)
2 more

1 mention without citation

Structural studies of CNG repeats.
Kiliszek et al. (2014)