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Structure of the first WW domain of human Smurf1 in complex with a di-phosphorylated human Smad1 derived peptide

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.2.26: HECT-type E3 ubiquitin transferase

Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Systematic name:
S-ubiquitinyl-[HECT-type E3-ubiquitin transferase]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming)
Alternative Name(s):
  • HECT E3 ligase
  • Ubiquitin transferase HECT-E3

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00397
Domain description: WW domain
Occurring in:
  1. E3 ubiquitin-protein ligase SMURF1

InterPro InterPro annotations
IPR001202
Domain description: WW domain
Occurring in:
  1. E3 ubiquitin-protein ligase SMURF1
IPR036020
Domain description: WW domain superfamily
Occurring in:
  1. E3 ubiquitin-protein ligase SMURF1

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