› 2lg1

Solution NMR

Solution structure of the human AKAP13 PH domain and stabilizing DH helix

Released:
DOI: 10.2210/pdb2lg1/pdb
PDB entry 2lg1 coloured by chain, ensemble of 20 models, front view.
PDB entry 2lg1 coloured by chain, ensemble of 20 models, side view.
PDB entry 2lg1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Lenoir M, Sugawara M, Kaur J, Ball LJ, Overduin M
OpenAccess logo J Biol Chem 289 23992-4004 (2014)
PMID: 24993829

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171398 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
A-kinase anchor protein 13 Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 21.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12802 (Residues: 2164-2346; Coverage: 7%)
Gene names: AKAP13, BRX, HT31, LBC
Sequence domains: PH domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Structural Mechanisms and Drug Discovery Prospects of Rho GTPases.
Smithers et al. (2016)
1 more

9 mentions without citation

Cell Biology of Intracellular Adaptation of Mycobacterium leprae in the Peripheral Nervous System.
Hess et al. (2019)
8 more