› 2lhm

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURES OF THE APO-AND HOLOMUTANT HUMAN LYSOZYMES WITH AN INTRODUCED CA2+ BINDING SITE

Released:
DOI: 10.2210/pdb2lhm/pdb
PDB entry 2lhm coloured by chain, front view.
PDB entry 2lhm coloured by chain, side view.
PDB entry 2lhm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the apo- and holomutant human lysozymes with an introduced Ca2+ binding site.
Inaka K, Kuroki R, Kikuchi M, Matsushima M
J Biol Chem 266 20666-71 (1991)
PMID: 1939116

Function and Biology Details

Reaction catalysed: 
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158303 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysozyme C Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.75 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61626 (Residues: 19-148; Coverage: 100%)
Gene names: LYZ, LZM
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P212121
Unit cell:
a: 57.06Å b: 60.62Å c: 33.81Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 not available not available
Expression system: Not provided

Quick links

Citations

5 review citations

The construction of metal centers in proteins by rational design.
Hellinga HW. (1998)
4 more

2 mentions without citation

Improving structure-based function prediction using molecular dynamics.
Glazer et al. (2009)
1 more